Featured Preprint: 3D-super-enhancers

bioRxiv

Building communities of enhancers and promoters using machine learning and graph theory.

Community co-activator signal significantly predicts expression.

3D-super-enhancers with very high signal include genes that are co-regulated within individual co-activator condensates.

Featured Preprint: KAT6A/B in neuroblastoma

bioRxiv

The reversible retinoic acid response of neuroblastomas is cemented by KAT6A/B-inhibition.

KAT6A/B inhibition rewires not only enhancers but also repression.

Combined KAT6A/B + retinoic acid treatment increases sensitivity to anti-GD2 therapy.

Featured Publication: STAT3 anchors the ALCL core regulatory circuit

Cell Reports Medicine

Hyperactivation of STAT3 unifies anaplastic large cell lymphoma subtypes.

Hyperactivated STAT3 invades ALCL enhancers genome-wide.

The ALCL core regulatory circuit collapses when therapies that directly or indirectdly target STAT3 are used.

The Abraham Lab at St. Jude

We are an interdisciplinary lab focusing on computational biology approaches to identifying, studying, and perturbing transcriptional processes toward therapeutic gains, largely in pediatric cancers. We reside in the Brooks Brothers Department of Computational Biology at St. Jude Children's Research Hospital in Memphis, TN, USA. Our ongoing collaborations include disease experts in multiple pediatric cancers and proto-therapeutic chemistries and are based at St. Jude, Dana-Farber Cancer Institute, and beyond. Our research is supported by ALSAC, St. Jude, and the National Cancer Institute.